Scripps college map12/30/2023 Professor and Chair of Genetics and Cellular Physiology, Hudspeth is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the American Philosophical Society. They also investigate the replacement of hair cells as a potential therapy for hearing loss. He and his colleagues are especially interested in the active process that sensitizes the ear, sharpens its frequency selectivity, and broadens its dynamic range. Hudspeth conducts research on hair cells, the sensory receptors of the inner ear. After joining the Howard Hughes Medical Institute, he moved to The Rockefeller University, where he is the F.M. Kirby Professor. Following postdoctoral work at the Karolinska Hospital in Stockholm, Sweden, he served on the faculties of the California Institute of Technology, the University of California, San Francisco, and the University of Texas Southwestern Medical Center. He received his PhD and MD degrees from Harvard's Graduate School of Arts and Sciences and Harvard Medical School. Hudspeth was born and raised in Houston, Texas, and conducted his undergraduate studies at Harvard College. Investigator, Howard Hughes Medical Instituteĭr. In 2018 he shared the Kavli Prize in Neuroscience with A. Fettiplace is a Fellow of the Royal Society of London and Fellow of the American Academy of Arts and Sciences. His research culminated in providing evidence for the contribution of the transmembrane channel-like protein, TMC1, as the mechano-transducer channel in mammalian cochlear hair cells. Fettiplace became the Steenbock Professor of Neuroscience at the University of Wisconsin-Madison, where he researched the properties and location of the mechanically sensitive ion channels underlying sound transduction. He first used photodiode imaging to track the nanometer motion of hair bundles, enabling description of their mechanical properties and spontaneous oscillations. He and Jon Art showed that a hair cell's electrical tuning frequency is determined by the number and kinetics of its Ca2+-activated K+ (BK) channels, implying that distinct kinetic forms of the BK channel encode different frequencies. With Andrew Crawford, he described the sensitivity and frequency tuning of auditory hair cells and discovered that individual turtle hair cells were electrically tuned to specific frequencies arranged along the cochlea like keys of a piano. In 1976, he returned to Cambridge University and continued research on turtles but switched to studying auditory transduction. Fettiplace studied at Cambridge University in the United Kingdom, obtaining a BA in medical sciences and a PhD in biophysics, then joined Denis Baylor at Stanford University for postdoctoral work on turtle photoreceptors. Professor of Neuroscience, Department of Neuroscienceĭr. Weissman’s lab develops methods to replace genetically deficient proteins, edit the genome, and specifically target cells and organs with mRNA-LNPs, including lung, heart, brain, CD4+ cells, all T cells, and bone marrow stem cells. They continue to develop other vaccines that induce potent antibody and T cell responses with mRNA-based vaccines. Weissman’s lab created is used in the first two approved COVID-19 vaccines produced by Pfizer/BioNTech and Moderna. The nucleoside-modified mRNA-lipid nanoparticle vaccine platform Dr. Katalin Karikó, discovered the ability of modified nucleosides in RNA to suppress activation of innate immune sensors and increase the translation of mRNA containing certain modified nucleosides. He received his graduate degrees from Boston University School of Medicine. Weissman is professor of medicine at the Perelman School of Medicine, University of Pennsylvania.
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